Ok i just ran Witcher 2 this is near the start with the dragon part.
High spec Screen rez 2560x1440 was getting between 30-40FPS
Ultra spec screen rez 2560x1440 was getting 10-12FPS
Ultra spec screen rez 1920x1080 was getting around 20-25FPS
I also switched my graphic cards round as the one the DVI is plugged in was makeing a lot of noise the same as and XBO360 would after a while of play.
Seems the other one is much quieter as hardly makes any. does this mean there may be a problem with that one?
Turn off UBER SAMPLING

My single GTX 580 gets a solid 60fps without it on.
Turned on I drop to 10-15 fps.