You might want to tell that to every review site out there who thinks its a valid comparison, its still a single card regardless of how many gpu's are on it. Yes there can be issues with multi gpu's and drivers but its never stopped the cards selling, and because of the cap system issues for newer games are usually resolved pretty quick. And unless AMD's strategy on the gpu side of things has changed recently they stopped going for uber high end single gpu cards and instead left that to the dual gpu board, been that way since the 3870x2 following the 2900xt debacle. With my time running 3 gpu's the only games I had issues with were Rage, and battlefield 3, and both of those issues were sorted out pretty quickly.
Not really, if someone wants to do quadfire or trifire and has limited space in their machine 2 7990's or a 7990 and a 7970 is the perfect solution. It'll also probably draw less power than having 3 or 4 individual cards. its also a solution that isn't available for nvidia cards as you can't link a 690 and a 680 for example together.
Two HD 7990s in quadfire is a very bad move, have a read of this review
http://www.tomshardware.com/reviews/radeon-hd-7990-crossfire-overheat,3539.html
By comparison 4 air cooled Titans are quite easy to keep cool in a decent PC case.