I would go for one big bathroom with two doors so it can be accessed from the bedroom or landing.
We have a bathroom and ensuite and barely use the main bathroom
I quite like this idea, we have friends with this type of setup.
Personally I like having an ensuite as it somehow feels a bit more private when you have guests etc. I do wonder however if they will go out of fashion at some point i.e. in 30 years time people will turn their noses up and view them with the sort of disdain currently reserved for 70s decor or carpets in bathrooms .