I think Southampton will struggle without Bertrand and Clyne today, we at least have a replacement left back in Targett but from the lineup I'd guess Yoshida has been shoved to right back, which is nowhere near Clyne strength in that position, certainly not from an offensive perspective.
The front end of the team looks OK though, decent strength there.
Southampton: Forster, Alderweireld, Fonte, Yoshida, Targett, Steven Davis, Wanyama, Schneiderlin, Tadic, Pelle, Mane. Subs: Kelvin Davis, Gardos, Long, Ward-Prowse, Isgrove, Reed, McCarthy.