and this is why you cant use a single source
for a start bioavailabilty can be increased by taking it with other things.
here's just one of dozen of studies listed on examine.com
Turmeric? Any good?
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for a start bioavailabilty can be increased by taking it with other things.
here's just one of dozen of studies listed on examine.com
IIRC you need fairly silly amounts to get notable benefits, not very cost effective.
I remember one morning pouring half a canister of nutmeg into my porridge and just decided to mix it in and eat it, 8 hours later I started acting pretty weird, went through what I’d ate and googled the stuff and found it’s psychoactive in larger quantities lol
I remember one morning pouring half a canister of nutmeg into my porridge and just decided to mix it in and eat it, 8 hours later I started acting pretty weird, went through what I’d ate and googled the stuff and found it’s psychoactive in larger quantities lol
IIRC you need fairly silly amounts to get notable benefits, not very cost effective.
I remember one morning pouring half a canister of nutmeg into my porridge and just decided to mix it in and eat it, 8 hours later I started acting pretty weird, went through what I’d ate and googled the stuff and found it’s psychoactive in larger quantities lol
Username checks out.
cant say i really know the answer following on from my earlier post but will continue using based on my own experiences ,not just googling
Anti-inflammatory activity
Curcumin has been shown to inhibit mediators of the inflammatory response, including cytokines, chemokines, adhesion molecules, growth factors, and enzymes like cyclooxygenase (COX), lipoxygenase (LOX), and inducible nitric oxide synthase (iNOS). Nuclear factor-kappa B (NF-κB) is a transcription factor that binds DNA and induces the transcription of the COX-2 gene, other pro-inflammatory genes, and genes involved in cell proliferation, adhesion, survival, and differentiation. The anti-inflammatory effects of curcumin result from its ability to inhibit the NF-κB pathway, as well as other pro-inflammatory pathways like the mitogen-activated protein kinase (MAPK)- and the Janus kinase (JAK)/Signal transducer and activator of transcription (STAT)-dependent signaling pathways (28). Inhibition of dextran sulfate sodium (DSS)-induced colitis by curcumin in mice has been associated with a downregulation of the expression of p38-MAPK and pro-inflammatory cytokine TNF-α and a reduction of myeloperoxidase (MPO) activity, a marker of neutrophil infiltration in intestinal mucosa (29). Curcumin has also been shown to improve colitis by preventing STAT3 activation and STAT3-dependent induction of cell proliferation in mouse colon (30). Moreover, curcumin was shown to attenuate the immune response triggered by collagen injections in a mouse model of rheumatoid arthritis, partly by blocking the proliferation of T lymphocytes in mouse splenocytes (31). In addition, curcumin has been found to reduce the secretion of TNF-α and IL-1β and the production of COX-2-induced prostaglandin G2. In one study, curcumin inhibited the secretion of matrix metalloproteins (MMPs) — responsible for the degradation of the synovial joints — in human fibroblast-like synoviocytes (31) and in human articular chondrocytes (32). Curcumin has also been found to alleviate neuro-inflammation in a mouse model of traumatic brain injury, reducing macrophage and microglial activation and increasing neuronal survival (33).
Anti-inflammatory activity
Curcumin has been shown to inhibit mediators of the inflammatory response, including cytokines, chemokines, adhesion molecules, growth factors, and enzymes like cyclooxygenase (COX), lipoxygenase (LOX), and inducible nitric oxide synthase (iNOS). Nuclear factor-kappa B (NF-κB) is a transcription factor that binds DNA and induces the transcription of the COX-2 gene, other pro-inflammatory genes, and genes involved in cell proliferation, adhesion, survival, and differentiation. The anti-inflammatory effects of curcumin result from its ability to inhibit the NF-κB pathway, as well as other pro-inflammatory pathways like the mitogen-activated protein kinase (MAPK)- and the Janus kinase (JAK)/Signal transducer and activator of transcription (STAT)-dependent signaling pathways (28). Inhibition of dextran sulfate sodium (DSS)-induced colitis by curcumin in mice has been associated with a downregulation of the expression of p38-MAPK and pro-inflammatory cytokine TNF-α and a reduction of myeloperoxidase (MPO) activity, a marker of neutrophil infiltration in intestinal mucosa (29). Curcumin has also been shown to improve colitis by preventing STAT3 activation and STAT3-dependent induction of cell proliferation in mouse colon (30). Moreover, curcumin was shown to attenuate the immune response triggered by collagen injections in a mouse model of rheumatoid arthritis, partly by blocking the proliferation of T lymphocytes in mouse splenocytes (31). In addition, curcumin has been found to reduce the secretion of TNF-α and IL-1β and the production of COX-2-induced prostaglandin G2. In one study, curcumin inhibited the secretion of matrix metalloproteins (MMPs) — responsible for the degradation of the synovial joints — in human fibroblast-like synoviocytes (31) and in human articular chondrocytes (32). Curcumin has also been found to alleviate neuro-inflammation in a mouse model of traumatic brain injury, reducing macrophage and microglial activation and increasing neuronal survival (33).
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Evidence based treatment that doesn't work for everyone. People are individuals and you can't lump them all in the same treatment program. I've seen the treatment they give people and I don't agree with some of the treatments because they need more individual treatment to the person. Lo and behold 6 months later they've changed to what I said originally and there's an improvement. I'm not a doctor but if something isn't working I try something else within reason. Admittedly Turmeric is something of a hail mary but we'll see.
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Thank you for that. Very helpful as it specifies curcumin and osteoarthritis and not rheumatoid arthritis like all the others I've seen.
do they exist? although i have high respect form them, there training in a fair few areas is outdated and they aren't specialists, so they don't have time to read modern research and keep up with everything, especially as they need a wide knowledge of most things, but this also makes their advice lacking. imo Gps are expected to treat to many things thelselfs rather than sending you on to the right specialist.Completely agree on the individual thing. You need to selectively find a decent GP
roll on AI doctors, i expect them to quickly become multiple times better.
What helped my father-in-law's arthritis in his knees was giving up on almost all red meat. There was some study a while back that said that red meat contained an enzyme that attacked joints and caused inflammation. Cutting back on red meat (still ate fish and dairy, often chicken) really helped a lot. They are not religious about it and will happily eat meat if that's what there is, but from a health point of view, his knees got massively better.
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Aren't specialists?
Specialists in preventative medicine.
Specialists in people with chronic diseases.
Specialists in people with complex co-morbidities.
Specialists in community medicine.
Not to mention the last true generalists including paeds and gynae.
Much like any profession you get good ones and bad.
Their annual appraisals require them to do self study and keeping up to date.
Source: I'm a GP
This is also ignoring the tremendous pressure primary and secondary care is at the moment. 10 minutes to listen , examine and diagnose possible multiple issues. Due to resources follow up with the same doctor becomes difficult and thus a poor experience for the patient.
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but you aren't specialists in anything, Gps lack a huge amount of knowledge that specialist who follow a single field will know, and i dont blame gps at all. its the system. as i said Gps should be able to refer people to specialists.
and yes im away you have to study, but again you can not study to the same degree as a specialist, your knowledge is far to wide and its impossible to keep it up to date.
and yes im away you have to study, but again you can not study to the same degree as a specialist, your knowledge is far to wide and its impossible to keep it up to date.
Get a phytosomal kind (like Meriva). It's phospholipid bound for increased bioavailability.
Although regular turmeric and curcumin are still shown to work in studies despite low bioavailability because your gut bacteria metabolize it.
https://www.ncbi.nlm.nih.gov/pubmed/29306322
https://www.ncbi.nlm.nih.gov/pubmed/29306322
"CONCLUSIONS:
Our results demonstrate that curcumin attenuates CIA through the "gut-brain axis" by modulating the function of the cholinergic system. These findings provide a novel approach for mechanistic studies of anti-arthritic compounds with low oral absorption and bioavailability."
Although regular turmeric and curcumin are still shown to work in studies despite low bioavailability because your gut bacteria metabolize it.
https://www.ncbi.nlm.nih.gov/pubmed/29306322
https://www.ncbi.nlm.nih.gov/pubmed/29306322
"CONCLUSIONS:
Our results demonstrate that curcumin attenuates CIA through the "gut-brain axis" by modulating the function of the cholinergic system. These findings provide a novel approach for mechanistic studies of anti-arthritic compounds with low oral absorption and bioavailability."
he's just listed some areas where he's a specialist though 
they can often also have a special interest too - like I know one who has additional qualifications in palliative care and another who has a special interest involving drugs and alcohol clinics
they can often also have a special interest too - like I know one who has additional qualifications in palliative care and another who has a special interest involving drugs and alcohol clinics
but he's not, he cant spend the time on those areas, that a true specialist can. I can pretty much guarantee his knowledge in several of those areas is lacking. you only need to know a couple of areas of research to know advice given out by gps in several areas is at best bad.he's just listed some areas where he's a specialist though
I'm pretty sure GPs can work full time too
what, that makes no sense.
Out of interest, do you think an A&E registrar or consultant is a specialist? How about a paediatrician?
If so what makes them specialists over a GP?
If not then how do you define a "specialist"?
You've just had an actual GP explain to you where he specialises and you're happy to just deny him that... that is what really makes no sense here.
It helps with my inflammatory diseases. It, along with other suplements, has allowed me to achieve the lowest dose of oral steroids in years.
EDIT: I take one that is combined with pipperine (an extract of pepper) to improve bioavailability.
EDIT: I take one that is combined with pipperine (an extract of pepper) to improve bioavailability.