yes, I've got the ASROCK 4xNMVe PCIE3.0 adaptor running Sabrent Rocket PCI4.0 NMVe drives (5500mb/s), but they max at 3500MB/S which is fine due to the PCIE3.0 slot.Gen 4 m.2 would probably* work in a regular PCIe to m.2 add-in card, just at 3.0 speeds.
*Haven't tried, 3.0 cards work fine though