If it's an AIO, yes.
Just shake the radiator, it's pretty obvious if there's gas inside, even a brand new unit will have some gas inside. The older the AIO, and the higher the fluid temperature is (linked to heat load vs radiator size), the quicker it will permeate through the tubing. E.g. a 240mm AIO on a Core i9 CPU will suffer quicker fluid loss than the same AIO model on a Core i5, generally speaking.
If you change your AIO every 4-5 years (Asetek gives a MTBF of 50k hours for their gen 4 and 5 stuff, not sure about the newest gen 6), you are not going to witness this problem, especially if you mount it correctly so the gas never have a chance to enter the pump. Most users only become aware of issues when something changes in their system (odd noise from gas trapped in the pump/block in this instance). It's only when you run the AIO past its rated specs (Asetek consumer units are supposedly tested to a fluid temp of 60c). Also keep in mind the models with bigger radiator have more fluid inside to counteract against permeation when mounted correctly.