I tend to leave the top of the res open (so air can escape), then lean the case this way and that to get the air bubbles out of the radiator, and blocks. When you've bled the system, the pump should quieten down a bit, as much of the noise you're hearing is the air in the pump.
I do this but leave the top on the reservoir in case any liquid is spilt whilst tilting the case.
Any air in the system will end up in the reservoir and you can just keep topping up as needed.
if I switch off my rig and the res still has some space in it for coolant will the loop fill up with the air in the res?