I wanted to see the larger picture of that. Looks like a system that will never be lacking, here the radiators at the end of the chain up or even downstairs will not get above lukewarm unless turning down the radiators closest to the boiler
Are you thinking of installing Solar PV (electric) panels at some point?
If so a cylinder is a good idea, as you can have an immersion and a solar diverter that diverts electricity thats not being used and would be exported to the grid into the tank to make hot water for free.
Works well for us, I wouldn't be without a cylinder for this reason alone.
After going from a combi to a cylinder. I would now always go with a cylinder.
How big is your house? How many people live there?
Boiler room
You need to check your flow via an unrestricted outlet. Taps can vary massively. This is our system. Complete re pipe etc. 3 floors 17 rads.
You wont need two boilers (unless its a big house) We also have secondary H/W circulation. this pumps hot water past all the hot water taps so as soon as we turn the hot water we get a second of warm water before its hot. Even at the far end of the house. This, I believe is more efficient in a big house or even a busy house, than having to draw off cooled hot water to get new hot water.
I cant really tell any difference in temp on the hot from the closest to the furthest so probably not that much of a temp diff between outlet and return.