Last holiday i took to Prague 3yrs ago (its been that long since i had a proper holiday ) I took my 5D2 along with 70 - 200mm f2.8 and a 24 - 70 mm f2.8. Didn't have any qualms about leaving my camera in my room (evenings mainly when i went for a few drinks). The biggest 'fright' i got was at the airport (Edinburgh) when some cack handed fool starts opening the bag not giving a crap about whats in it until the point i asked if he wanted to be paying out over £5k for all / anything he damages if anything falls out!