We went combi purely to save space, and instant unlimited hot water.I've not seen a cost break-down of the wasted energy/resources in purely-combi setups,
via a permanently on pre-heat mechanism or wasted water and energy meeting occasional demands, but, compared to joint combi/pressurized-hot-tank solution I had in last property, every time I use the dam system it's the main thought.
....Have an Ideal combi.
I went with an Ideal Vogue Gen 2. I really liked the screen on the boiler, no codes if anything goes wrong it tells you properly whats wrong and how to fix it.
The guy fitting it loved it as well as the screen gives him all the data he needed for commissioning and servicing. Gives you nice graphs showing everything.