It's physically impossible to build your own Ryzen motherboard today because they're too complicated.
That sounds like a challenge...
One of the problems though with building a motherboard for a desktop PC today is that a lot of the microprocessor controllers aren't available to DIYers, etc. you need a commercial license and/or minimum order quantities agreement (which usually runs into multiples of like 5000) not to mention soldering stuff like BGA and QFN by hand even if you have a hot air station.
I've built most of the integrated systems on motherboards on prototype board at one time or another for instance this is what you'd have for integrated sound:
(Normally a lot of those components would be SMD, etc.)