Aye, I'm all for an experiment
Just to add my 2GBp (Great British pence), I have a Cooler master HAFX with 2x 200mm top exhaust fans. As a random experiment I recently changed the front one to intake while leaving the one behind it as exhaust. I thought this might just make a mess of the airflow. But it seems to have improved the cpu temps by a few degrees (prime95) and I think even the GPU temp when gaming by 2/3 degrees. GPU less scientific as it's just playing MW, but I thought it was worth a try and I've since left it like this. Results may vary...