Fans: Normally, in fully water cooled systems the consensus is it is better to have fans drawing air from outside the case through the rad. However, since you still have an air cooled sink on the cpu, I would hazard a guess that the increase in ambient case temps this would cause would not be good for the cpu overclock, so I would have fans pulling out. Best to try both though to be sure.
PT Nuke. It doesn't matter when you put it in, as long as it mixes properly. Just put it in with you first fill. Pay attention to the dosage instructions.
Leaning: Once the lopo is sufficiently filled so water is going round the loop without you having to put more in, yhen you can lean the case about to your hearts content in order to get air out of the nooks and crannies it will collect, as long as you never expose the pump inlet to bare air. As to where air will collect, work on the basis that air left to its own devices will rise, so look at your loop and imagine where a bubble of air would go if it started at any point in the loop, and work out how you need to lean/rotate the case to get it out of that pocket.
Res: Once you've finished the main bleeding, put the plug on and leave it running. Come back a day later and top up if necessary.
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