I just changed my 8800GTX for a 5850 and now when I try to load up the game it tells me I need PhysX. I know that PhysX is nVidia only so my question is can I run the game somehow?
Have you tried running the configuration utility & setting your graphics options in that before you run the game? (right click on the ME2 icon in the games explorer in vista/win7 & select configure)
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