Definitely look into spending a few days in a cabin in the Smokies if you’re out that way.
We didn't do the cabin due to cost/not settled dates but spent 4 days in Pigeon Forge, although very touristy was a great base to get into the park. Spent Halloween there, which was incredible. Definitely an experience everyone needs to see.
Depends how long you have, we had almost 3.5 weeks which got us doing Texas, Florida too and there were only a couple of days where we spent most of it in the car, but interspersed with stops so it didn't ever feel like you were a slave to driving.