None. Areal density (more GB per unit area) is better as this means faster accessing of data (simplistically). Therefore big drives which use big platters are better.
However - your question depends on the RAID used. If RAID0, you want small drives because if it goes kaput, then you are more than likely to have less data to lose - and even that isn't a good reason.
I assume by small here you mean up to 80GB and large as 250GB and over. The middle ground is excluded.