I wouldn't DDU unless you don't have any other options left and if you absolutely want to then uninstall the drivers normally first. Reason being that sometimes things go wrong with DDU, atleast that has been my experience from time to time.New Driver is not so good for my 7900xtx... Getting seriously bad frame drops in WoW and a couple of games.
EDIT: Went back to 25.3.1 and everything is smooth again and I made sure that 25.4.1 was installed after DDU.