No problem running two quests off one router configured like you suggest. Location wise the proximity to the router is important, the length of the rum to the PC from the router won't have any impact if hardwired.
One issue will be you need two separate accounts and each will have to purchase the game if playing via the Oculus app, so that will add cost. I think the same would apply if using Steam VR but not 100%.
Thanks Dave, good to know one router all that's required - yes, had figured I'd need to pay twice, so not unexpected!