It helps a great deal......
I have the Asus RE3 board - which will (eventually) be pushing four fermi cards along with an i7 6 core cpu. It's not a cost effective solution - it's a personal project (kind of thing).
Yeah I've got 4 in mine, but only 3 are working, one died. Using an Asus P6T7WS
Make sure you plug every available power connector into the motherboard that there is, and don't use a board that doesn't have any extra power connector (I know the RE3 has two extras)
If you are part time then I probably wouldnt bother running bigadv but thats just me.
I would go into the web interface and shut it down there.