What are your 'must have' pieces of software?

[Dewotter]

FireFox
VMware
uTorrent
Spybot
Symantec Endpoint Protection
iTunes
Live Messenger
APatch (for messenger)
WinRAR
Office 2007

 

[strumpusplunket]

Many already mentioned here (big echo of Unlocker - absolute Godsend!), plus:

Karen's Replicator
mp3tag
Media Monkey
Songbird
Dropbox
Internet Download Manager
Acronis True Image

 

[chad]

foobar2000
only2clicks
firefox
winrar