how do you plan to use them?
OS + commonly used programs on SSD, Data + other programs on SSHD?
Raiding them in together to try to make 1 massive drive (not even sure it will work)
mirroring the SSD to the SSHD (most likely to cripple the SSD)
there are probably more ways to use an SSD + SSHD, both good and bad, but the general answer is yes, the 2 drives will work together, but how plan to set them up might affect their performance