I once spent about two hours in the middle of the night (you know how sometimes, against all common sense, you just have to fix something right away, even if it is 2 in the morning) trying to trace a really annoying high-pitched whining buzzing noise. I couldn't locate the source by listening, maybe because of the pitch, I don't know. So I altered fan speeds, recabled inside, booted with non-essential drives disconnected, moved the main HDD (which was mounted with a vibration damping kit anyway) to a different bay, in a different bay section, checked the cpu and graphics card coolers weren't vibrating, check that the graphics card itself wasn't vibrating (I had that once, quite odd)...and eventually gave up.
I realised that the noise was coming from my low-energy light "bulb". Had I not been doing all that in the middle of the night, I might have realised that the noise hadn't stopped when I powered my PC down for recabling, etc.