Been playing for a few hours now and I'm really not that impressed.
It just feels like a particularly good Fallout 3 mod, except with lower res textures and crappy voice acting (seriously someone dropped the ball here, it's TERRIBLE). Nothing seems to have been upgraded visual wise, the game opening sequence is pitifully bad, at least the exposition of Vault 101 was slightly emotional and then MASSIVE SUN GLARE OH LOOK WASTELAND thing when you came out of the vault seemed both reasonable and impressive, you got to see the memorial thing and ruined highways, in this you step out of a house and see some shacks and brown hills...
I am playing on Hardcore Hard and have yet to encounter ANYTHING resembling a challenge, ammo, money, water everything is incredibly easy to find or steal, enemies are painfully weak as well.
Music is pretty good though.