Yes, if you root it it will look and feel "normal" but you have options to add extras like Titanium backup.
But you can also go the next step and add a custom rom, these range from ones that look just like the standard HTC Sense interface but with the bloatware removed and extra bits added to custom roms that are based on the standard Android with no HTC Sense.
I went with a Rom that looks like the standard HTC interface (I like Sense) but has some extras but also has things removed giving you more memory space and its also quicker and the battery lasts longer than before.
Im using Pays 1.5 but he has just updated it to version 2.0 so ill probably flash with that later tonight.
Decided to root as I had to do a hard reset on my phone to try and fix the fault where my phone wont "see" the new HTC update and, even using MyBackup, it kind of screwed up settings.
Using root so I can use MyBackup and Titanium Backup properly....
Problem is I only have the SD card that came with the phone so I have had to back that stuff up and use this as a goldcard and then reformat it back later....