Feel like I'm in two minds about this...
The first one had some really great things about it. For one, it easily had the best sound design I've ever seen in a game, sets the atmosphere perfectly. The start was also brilliant when you have no weapon and you just have to run for it!
What I didn't like was the fact that your character didn't speak and basically you just had characters who talked at you and told you what to do the whole time, while they sat about doing nothing. That spoiled it for me, a bit like the Rookie in Halo ODST... though it sounds like they have changed that.
It also started to feel a bit too repetitive, for example...
"The Life Support is Offline, Issac you need to fix it!"
"Issac, that's great that you got Life Support back on, but the engines are offline!"
"Issac, the engines are back online, but there is a fuel leak you need to fix!"
*Yawn*
Also, while it is a game that does make you jump at times, you get to the stage where you know that when you walk into an empty room, something is either going to come from behind you, or once you've done something in the room they will then all come at you.
I really hope they have worked on these issues.
As for the multiplayer it seems to have a real L4D feel, so will be interesting to see how it works out.