You may wish to change the network usage preferences so that you end up with several days' worth of WUs. Mine's set at 4 days + 1 additional day, which results in me getting several hundred WUs on my quad-core rig... handy for getting through those inevitable outages.
The only other thing is making sure which WUs you're getting. SETI has two sub-projects: Mainbeam (SETI Enhanced, or the bog-standard WUs) and Astropulse (far more detailed but the WUs for that take far longer to crunch). I can't remember the default settings, but if you want to receive WUs for both projects ensure that there's a tick next to SETI Enhanced and Astropulse v5 (ignore the Astropulse option; as far as I'm aware there are no WUs being produced for this anymore). For reference, my
[email protected] takes around 9-10 hours for an Astropulse WU but only ~1hr 30 for the standard ones, so it's up to you if you want to run Astropulse.
The optimised apps get through WUs quicker - far quicker, in some cases - with the rather obvious result being that you get work done faster and, therefore, more credit...
If you get time, have a peruse
here to find the appropriate app(s). Of course, it's not necessary to use optimised apps - but it does make sense and I strongly recommend them. However, you'll have to ask someone else about the GPU apps because, having never used them, I haven't a bloody clue