I dont know how we're supposed to tell the PPI or your resolution with those small screenshots.
Also, that extra sharpness is almost assuredly because your SweetFX profile has extra sharpness added, ruining the image quality quite badly. I mean, it's preference and all, but it's amazing all the screens of The Witcher 3 I've seen where people have the sharpness up to the full setting(which is already way too much) and then add even more with SweetFX making a painful looking screenshot.
Lastly, depth of field really only takes effect in conversations and VATS. Any blurriness is likely coming from your anti-aliasing setting, either FXAA or TAA(cant tell cuz your screens are too small). Both of these are preferable to no AA, though.
Anyways, just some constructive criticism/advice.
Also - take full size screens man. Want to see it in full glory.