On some SM heavy sites (icanhazcheezburger etc) it takes the page loading time down from an average of 12-15 seconds to an average of 5-6 seconds, plus a lots of bandwidth saved!
Off-topic from the main thread: is icanhascheezburger classed as SM? It's similar to Something Awful, Rathergood and B3ta. They all have funny videos and image contests and while they're usually user-created, I didn't think it was classed as SM? I checked out icanhascheezburger just now and it's pretty much the same as how I've always known it. B3ta is my favourite out of that bunch.
On-topic: I use uBlock as well although I'm interested to see how Ghostery compares as I didn't realise it was a blocking tool.
Another one to consider is NoScript which turns JavaScript off by default and then you can start whitelisting primary domains while blocking off-site domains. You can also hide elements of a web site which is remembered for later visits.
Also to consider is Greasemonkey, or anything that ends with -monkey e.g. Violentmonkey or Tampermonkey. Once installed, you can search for scripts (Greasyfork is a good site) that can block stuff such as Facebook's "sponsored" and "suggested" posts. These scripts can also augment a site (so the opposite of blocking). An example of this is adding CamelCamelCamel pricing history on Amazon product pages, as a chart that appears next to the product image.