Rroff, i've been using Quadro that long i'm unsure how different if any the 2D colour output is compared to Geforce. I do a Geforce card on my HTPC but without putting card with same monitors it's hard to tell any exact difference. Your correct the drivers are main difference, being they not focused on games releases, plus with Quadro I have Nview software that's quite useful.
arc@css, never knew about flux, however Windows 10 does something very similar as standard, and do have this enabled for night time work.
Things to reduce eye strain I know.
1) The BenQ screen bar, I only found this 4 months ago, it's brilliant for night working.
https://www.benq.eu/en-uk/lamps/computer-desklamp/screenbar-plus.html
2) Make your fonts a little bigger
3) Set your gamma control / contract / monitor colour control etc, takes ages to get correct, but it's worth the investment in time.
4) Run 3 monitors and run a quality monitor stand, I'm running an Ergotron LX triple, however all my screens are at eye level. The stand is old but still one of the best.
https://www.youtube.com/watch?v=EbGs0xp-4VY
5) Finally I use Ag Neovo glass fronted monitors, i'm the only person on this forum that runs them, but then i'm a bit oddball! but I swear the glass on them reduces eye strain. One thing my Ag Neovo's are not the latest ones, and they use technology prior to the LED technology, and I suspect the older technology although not as efficient on power, was kinder on eyes compared to the modern blue back lit LED's we have now.
So arc@css there my tips for reducing eye strain.