there is a lot of problem with the game, and the main ones are around DX12 or GPU settings
try removing all overclocks, i found when my GPU is overclocked it was crash to desktop.
Just a heads up but I’ve been running with a reasonable OC since day 1 and it’s still working fine for me. In fact the only time it’s ever CTD was when I wasn’t running the latest driver.
Already running the latest driver I take it?