Not sure how it matters or not but I see that they are using a variant of the Unity engine again for CS II.
Remembering how CS1 performs with many mods, seemingly main problem for performance, and how much it will use with memory, with a stack of custom assets, I am hopeful that CS 2 improves on that. How important that is for the Devs we will find out. At around 400k or so in population, along with mods and plenty of assets, the speed of the game gets quite compromised. Agent limits being something that could factor before then.
It has been a while since I played CS but, IIRC, it would take 3 seconds on a new map for one day and night cycle at 3x speed and then 9 seconds at 1 x speed. I used to use that as a guide, rather than just fps, to give an indication of how bad things were slowing down.
I liked the idea of using 25 tiles and creating larger cities around the map. But, due to limits, they often resembled ghost towns from a post apocalyptic world with very few people etc being rendered, compared to the population stats.