Running memory on Ryzen out of sync is simply not worth it unless it's for benchmarking when bandwidth is king.
I've managed to get my 4000C14 kit to boot up to 4533C16 stable and my memory latency was still worse than what it is at 3800C13. Fairly close but still a few ns off. Bandwidth was amazing, but as I said unless you need the bandwidth for something it's better to prioritize latency.
Sadly it does not look like AMD will get AM4 chips safely to 2000. Very few can manage it fully stable.
Whereas on my daily I get around 54ns
Around 54ns pretty much being where most people will sit with a 5950x.