Well you can up the voltages to help with any OC that you do manage to achieve.
You will need to use the OC bios from hardocp's forums and you are effectively overclocking by upping the fsb so having fast memory helps. Also you really need to put heatsinks on many of the motherboard chips once you start overclocking and have good airflow across the mobo as well as good cooling for the cpus.
Take a look at the guide
here at hardforum where the OC bios for Supermicro boards was made.
Just remember be very careful when flashing the bios on these expensive motherboards you can brick the board by using the wrong or missing switches in the flashing tool