I need an epic prank for use on my housemate.

You could put flour/talc in your friend's car air vents. Bonus points if you can turn up the fan so it is on high when he starts the car.
 
teabag under the shower head = tea shower

using your shampoo then top it up with something else nice e.g. urine or mr muscle oven cleaner
 
Buy a bulk load of cheap plastic cups and them fill them with water and put them in literally every single possible place in his room, on the floor, on every surface. Will take ages to manually remove them two at a time at most.
 
Another classic, it’s great as a revenge prank. Everyone has that really annoying friend that eats really loudly, every bite worse than the last, the box of Rice Krispies never ending, Snap Crackle and Pop! Now in the video below they apparently used a real dead bird, but fortunately with advances in technology fake dead animals can look pretty realistic these days, and at reasonable prices too. Stick one of those bad boys in your friend’s cereal box and wait for the chump to pour himself a bowl, after all breakfast is the most important meal of the day.

Pros: He may throw up.
Cons: You may throw up.

Video Preview: http://www.youtube.com/watch?feature=player_embedded&v=Sw7RxrozfO4
 
When he's out, spray copious amounts of expanding builders foam under his door, the foam will expand and solidify, making the door and the floor join as one.
 
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Stink bombs in his room at 3am whilst he's sleeping tbh.

Yeah this, so deffo this! You don't need many, maybe 3 or 5. You could either set them up like a minefield on the floor, or as booby traps. E.g. place one under his computer keyboard, its weight alone not enough to break the glass, but will break upon combined weight of hands+keyboard.
 
I love the fact you guys are continuing despite the fact he's read probably all of it :D

Maybe we can overcome him with sheer volume of pranks.

Of course, I have many of own that I'm preparing :)
 

Lol...

However if that was my uni room (or any of my friends too i think) i would do something like klinsmann into them all then throw them out the window.

If you are going to do something to make them work, do something like turn everything upside down. One of our mates 3 of us turned his large wardrobe upside down, every item in his room including a huge old 42" plasma tv and 100 odd dvds that we all sorted alphabetically in a rack. We also swapped the dvds around in their cases and move their positions on the rack... We did leave goonies in the correct case and the right way up though

It took him hours to sort just the dvds, finding their right cases
 
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