It can long term (causes it to 'go off' sooner) but co2 is a short term 'get me home' on road tyres which you remove and replace with 'real' air (due to the higher pressure, it'll leak overnight). CO2 slowly permeates rubber.Supposedly co2 can react with the sealant?
May be worth a google.
Have been running tubeless on my road tyres, 32mm wide Specialized Roubaix Pro '2bliss'. 10/11 months & nearing 3000 miles without a single flat. Amazing tyres for the price - £30 a pop is about the cheapest amongst road tubeless tyres.If you are going to go tubeless (the best thing you can do especially with winter around the corner) then its worth getting the right pump. I had so many issues trying to seat tyres before and now i just blast 240psi into it
When stripping this sealant I've found 6 thorns in the casing (with evidence of at least 2 more), had thought I was lucky avoiding them, but they're all there and been plugged by sealant without any evidence of sealing on the outside or loss of air. I'm really impressed and the pain of removing these bogies is a good compromise for not having to stop for 6+ tube changes!
Did try scrubbing it in water without much change but hadn't tried hot water.As for removing the old sealant - I've just left the tyre in a washing up tub with hot water for 10-15 mins and it generally wipes off.
Consistency & regularly riding is key!Went a couple of weeks ago though and my god my fitness (the bit that i had) has just disappeared