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Not really.
A 280mm rad has to go on the side. With a rad on the side, you can't mount a PSU at the front. It may be possible to mount an ATX PSU on the other side (i.e. the SFX position), but this would limit GPU length to maybe 190mm (ish). You might then be able to mount two 3.5" drives on the case floor at the front.
If you need a large GPU as well then the answer is definitely no. There just isn't that sort of room in this case. Even with an SFX PSU, it would be a choice between the radiator or the drives.
Yea only thing my Phanteks Enthoo case lacks is triple slot for GPU, and the rest of the newer triple slot ITX cases lack the rest of the expansion options.