They've already scrapped the game once as it was 'too close' to WoW and the modern mmo, I expect it will be a 1 on your list (as long as it doesn't impact on the 'game' I dont mind - i.e xp boosts, cosmetic items). Smedley has also used the sandbox term a lot, so I'm hopeful we won't have "!" questing (GW2 is the future of questing imo).
I *think* more GW2 with Neverwinter style user generated content than WoW personally.