Police: Here's a statement from officers on the crash.
A GMP spokesman said: "Motorists are advised to avoid an area of Manchester near to the University following a collision.
"Just after 7.30am on Tuesday 13 January 2015, police were called to Upper Brook Street following reports of a collision involving a cyclist and a Honda Jazz car.
"The cyclist, a man, suffered a serious head injury in the collision and has been taken to the Manchester Royal Infirmary where his condition is described as critical.
"There are currently a number of road closures in place in the Upper Brook Street, Booth Street, Cabot Street and Brunswick Street areas and there is already a heavy build up of traffic so motorists are advised to find alternative routes.
"Anyone who witnessed the collision is asked to call police on 101"