Could be a dodgy mouse, USB port or motherboard issue.
Try a different mouse.
Reinstall motherboard USB drivers.
Try your current mouse on a different PC/laptop if you can.
If you have another monitor, set up twin monitors and have task manager performance open on the second screen. Watch for CPU spikes or other strange happenings when moving mouse.
EDIT ^^ Seen you already done this.
You say 20min in, is that from PC start-up or PC was running for over 20min when you started the game?
If its a time issue then It could be the CPU, clock it down and see if it still happens.
Also cannot rule out a memory issue.
Remove sticks of ram and check.
Try a different mouse.
Reinstall motherboard USB drivers.
Try your current mouse on a different PC/laptop if you can.
If you have another monitor, set up twin monitors and have task manager performance open on the second screen. Watch for CPU spikes or other strange happenings when moving mouse.
EDIT ^^ Seen you already done this.

You say 20min in, is that from PC start-up or PC was running for over 20min when you started the game?
If its a time issue then It could be the CPU, clock it down and see if it still happens.
Also cannot rule out a memory issue.
Remove sticks of ram and check.
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