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These constant driver crashes...
I've been using the latest hotfix driver on 2 separate systems without issue. A 980 in one, and a 980Ti in the other.
Stock.
Well, after further trials, Borderlands 2 is stable with stock clocks. One of those games that doesn't run with a manually OC'd card, but fine with the factory overclock.
Weird.
But at least I get to play it again!
That is strange, it's not the most demanding game graphically. PhysX on the other hand is pretty taxing in BL2.
Did you try lowering/disabling PhysX to see if it helped when OC'd?