It's all about wormholes for making isk
Kill and loot anything that isn't an ally and run all the sites you can find. Far more fun than missions/mining, huge profits to be made and doesn't require a big hauler and loads of time studying the markets like trading does!
Wormholes are high ISK but high risk to (which is one of the reasons they are more fun than empire) - if your not thining 2 steps ahead you will die a horrid death and even that doesn't guarantee your safety.
The less ethical methods are often the most profitable. Scamming, corp theft and suicide ganking are pretty profitable if you can be bothered. If you want something legit, trading is supposed to be good if you have the inclination.
Doesn't get much more profitable than this

http://eve-kill.net/?a=kill_detail&kll_id=10280292
That said I don't really consider suicide ganking that unethical - you can take some simple precautions to minimize the chances of it happening to you (not undocking in an amplification node fit tengu with no buffer being one) - tho at the end of the day if someone wants to sit 30 gank maelstroms off the gate/station your in they are gonna get you in the end whatever your in.
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