Yes, I've lost about an hour and a quarter of screen-on-time even after optimising everything, S10 not S10+ though.
Actually was ok-ish for the first day after the upgrade but then started dropping like a stone - 8% per hour with the screen off, 17% per hour with the screen on and that's not even gaming, just browsing and Facebook and such. Two factory resets in three days, that was a week ago, an I haven't reinstalled some of the apps I wasn't really using, it's still about an hour an a quarter SoT less than before. Battery drain overnight when the phone is obviously idle was about 4% before, now is around 6%. (Wish it was the same as my old HTC 10, that would only drain 1% overnight!)
GSAM is showing "Android System" and "Kernel (Andoird OS)" are consistenly the highest draining "apps" thought neither never even appeared before without scrolling way down the list, accounting for about 30% of the total drain between them.