a combination of Luvoir and JWST can discover habitable planets with life (if they exist)
jwst has the equipment to be pointed towards already identified goldilocks planets and observe if they have oxygen and water and then in 2040 when Luvoir launches we'll be able to point it at those planets with water and oxygen and observe the biological signs of life.
Unfortunately even if in the 2040s we happen to discover planets with life, we can't get there but we can send equipment there to try and make contact (with even that can yield nothing given how fast life blooms and then fades in the Universe, even if we find life by the time we get equipment to that planet it may already have turned into Mars)