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I wouldn't recommend the MSIs for crossfire, I'm not sure about the rest.
I wouldnt recommend Crossfire on any card at the moment (or SLI for that matter).
However, if the results of the first proper iteration of DX12 MGPU are to go by, then the future may be a bit brighter for those with multiple cards. They have the RX480 using DX12 MGPU on Deus Ex Mankind Divided and have got 59% scaling at the first attempt which will inevitably get better as they go along. The best thing is, is that it improves on the Frametimes too, so the performance is smooth.
https://youtu.be/86tp-qRKG58