I agree with Castor regarding the limb loosing stuff 
Anything that happens to any of the characters like that especially the main character/leader is a pretty big deal and would make for great viewing IMO.
As Jay has pointed out certain stuff has already been put in motion as we have seen from episode 13 of S2 and is pretty obvious that they will follow the plot in the comics, however, as we all know, it will not be the same regarding timing of events and some events may not even happen and I wouldn't be surprised if they throw in new scenes, side story lines etc.

Anything that happens to any of the characters like that especially the main character/leader is a pretty big deal and would make for great viewing IMO.
As Jay has pointed out certain stuff has already been put in motion as we have seen from episode 13 of S2 and is pretty obvious that they will follow the plot in the comics, however, as we all know, it will not be the same regarding timing of events and some events may not even happen and I wouldn't be surprised if they throw in new scenes, side story lines etc.