I always start with a twin line system, it's easier to continue rather than then try to turn a 1 line system into 2. I normally build a long route run of oil/coal which makes 50k+ per run then supplement that with vehicles.
Seconded, but use Coal, Iron ore, or Wood as they have no max time limit for delivery, there's a gain when delivered faster but negligible in real time unlike stuff like goods, grain, livestock, passengers, mail and valuables which when not delivered a after a particular time, just give very little income at all.
Oil is okay too but I avoid it on temperate maps as the oil fields run out very soon, only reliable oil sources are oil rigs but they are too expensive to each per train only early on.
Perhaps interesting for ya :

EDIT: hmmm seems I misunderstood it myself, the mentioned goods just give less of a penalty, upto 0.4%.day after max delivery time, while the others give 0.8 % penalty a day once they reach the 2nd delivery date...
It seems Oil and Wood are the best to transport over very long distances, and coal has to be delivered quite quickly

( with quite quickly, I mean you cant rly transport it over the whole map, in sp im doing a 2048x2048 game and grains & livestock hardly makes any profit moving it half over the world, while coal is still fine)
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