Duke Nukem 3D patched with eduke32 and its running really well under Windows 10.
I came here to say I am playing Duke 3D too, for the first time. Except I built a Windows 98/DOS PC for this and Heretic, Doom etc:
MSI Slot 1 440BX Motherboard
Pentium III 450MHz (no fan needed)
Nvidia TNT2 (What I had lying around, doesn't really matter in DOS games and again no fan needed)
Soundblaster AWE32
The loudest part of this PC is the harddrive as the modern PSU is very quiet (I doubt the PC is using 50 watts).
Anyway having a lot of fun on DOS Duke 3D! I forgot what it was like having to search for all the secret areas in games!