Portrait for shooters, landscape for racing is the current thinking.
Kyle from HardOCP has a portrait setup, video here (scroll down & seek forward a few minutes): http://hardocp.com/article/2010/02/11/dont_buy_global_agenda_editorial/
I am watching that long Eyefinity review video. It has a lot of great observations.
The bezels, or the room in-between each Eyefinity monitor, can be a graphical challenge. Like if something like a tree goes from one monitor to the next. the tree will not line up from monitor to monitor, and it will look like there are 2 trees as a result. A person's face can look like it has 3 eyes if it gets caught in-between the monitors! But the guy in the revies said that ATI is working on a fix for this issue.
At 30:25 (min:sec) of the Eyefinity Review Video, he shows Crysis being played in Eyefinity. Note where the HUD elements are.
I could see myself using a setup like that. But I am sure 3 monitors like that do not come cheap.
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