I have only seen highlights of Chile against the Swiss and 1 half against Honduras but:
Both teams like to control the pace of the game, due to the higher quality and depth of the Spanish midfield, I believe Spain will hold the advantage here, judging by the quantity of cards issued in the Swiss game, I can see the Chileans becoming frustrated and perhaps playing more aggressively, and I wouldn't be surprised if one of their players was sent off.
Spain like to faff, particularly in front of the goal, whilst Chile seem unable to convert every chance, I can see Spain holding most of the possession with Chile attacking fast on the break, I don't think Spain will escape without conceding but I believe ultimately they will triumph, my prediction: 2-1